GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs573521 | 1 | rs602128 | chr11:102713465 | MMP1 | chr11:102660641-102668966:- | 0.25 | 4.48 | 9.55E-6 | Cerebrospinal fluid levels of Alzheimer's disease-related proteins |
| THCA | cis | rs16958440 | 1 | rs60228288 | chr18:44640412 | HDHD2 | chr18:44633782-44676871:- | 0.26 | 4.99 | 8.46E-7 | Sitting height ratio |
| THCA | cis | rs16958440 | 1 | rs60228288 | chr18:44640412 | PIAS2 | chr18:44392061-44500123:- | -0.15 | -3.36 | 0.000847 | Sitting height ratio |
| THCA | cis | rs6499255 | 1 | rs60231938 | chr16:69830415 | COG4 | chr16:70514473-70557457:- | -0.19 | -3.83 | 0.000144 | IgE levels |
| THCA | cis | rs2129782 | 1 | rs60245117 | chr8:89438405 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6911965 | 1 | rs60251819 | chr6:24468648 | GMNN | chr6:24775159-24786276:+ | -0.28 | -3.74 | 0.000203 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs60251819 | chr6:24468648 | GPLD1 | chr6:24428405-24489850:- | 0.25 | 4.7 | 3.46E-6 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs60251819 | chr6:24468648 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.44 | 8.49E-8 | Hematological and biochemical traits |
| THCA | cis | rs6099314 | 1 | rs6025229 | chr20:55452397 | CBLN4 | chr20:54572497-54580012:- | 0.21 | 3.5 | 0.000514 | Chronic obstructive pulmonary disease (moderate to severe) |
| THCA | cis | rs7762018 | 1 | rs60253563 | chr6:170083019 | C6orf70 | chr6:170151721-170181617:+ | 0.27 | 5.21 | 2.78E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs7762018 | 1 | rs60253563 | chr6:170083019 | WDR27 | chr6:169857307-170102159:- | -0.2 | -5.91 | 6.66E-9 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs6472235 | 1 | rs60258162 | chr8:66845886 | PDE7A | chr8:66629906-66753755:- | 0.17 | 3.82 | 0.000154 | Myopia (pathological) |
| THCA | cis | rs4959799 | 1 | rs60267481 | chr6:3291109 | PSMG4 | chr6:3259162-3268300:+ | -0.33 | -5.52 | 5.44E-8 | Survival in rectal cancer |
| THCA | cis | rs6028335 | 1 | rs6028335 | chr20:37845477 | DHX35 | chr20:37591000-37668363:+ | -0.26 | -6.23 | 1.0E-9 | Alcohol and nictotine co-dependence |
| THCA | cis | rs6030712 | 1 | rs6030712 | chr20:35637398 | RPN2 | chr20:35807456-35870023:+ | -0.24 | -4.12 | 4.47E-5 | Height |